张长青

姓名：张长青

电邮: cquintonzhang@outlook.com

学习经历

2000.08.-2006.05.美国亚利桑那大学植物科学专业 获博士学位（导师：David Galbraith）

1993.09.-1996.07.中国农业科学院 植物遗传育种专业获硕士学位（导师：贾士荣）

1987.09.-1991.07.河北农业大学 作物遗传育种专业获学士学位（导师：马峙英）

工作经历

2021.06-现在    河南大学作物逆境适应与改良   攀登计划特聘

2013.07-2021.05       美国北卡罗莱纳州立大学     Senior Researcher

2008.04-2013.06       美国德克萨斯大学奥斯汀     博士后

2006.05-2008.03       美国亚利桑那大学         博士后

1996.07-2000.08       中国农业科学院生物技术中心  助研

1991.07-1993.08       河北省高碑店市方官镇农技站  农技员

主要成就

长期从事植物功能基因组学与表观遗传学方面的研究工作，在PNAS、Nature Communications、PlantJournal等学术期刊发表SCI收录论文20余篇。

发表论文

1.Zhang, M., &Zhang, C.^#(2024). Preferential cleavage of upstream targets in concatenated miRNA/siRNA target sites support a 5'-3' scanning model for RISC target recognition. (2024)Biochemical and biophysical research communications,703, 149662. https://doi.org/10.1016/j.bbrc.2024.149662

2.Han, Q., Hung, Y.H.,Zhang, C., Bartels, A., Rea, M., Yang, H., Par,k.C., Zhang, X.Q., Fischer, R.L., Xiao, W., Hsieh, T.F. (2022) Loss of linker histone H1 in the maternal genome influences DEMETER-mediated demethylation and affects the endosperm DNA methylation landscape.Frontier in Plant Science. 2022 Dec 22;13:1070397. doi: 10.3389/fpls.2022.1070397. PMID: 36618671; PMCID: PMC9813442.

3.Pecorellia, A., Cordonea, V., Messanoa, N.,Zhang, C., Faloned, S., Amicarellid, F., Hayeke, J., Valacchia, G. (2019) Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation.Redox Biology, doi.org/10.1016/j.redox.2019.101334

4.Zhang, C.*,Hung, Y.*, Rim, H.J.*, Zhang, D., Frost, J.M., Shin, H., Jang, H., Liu, F., Xiao, W., Iyer, L.M., Aravind, L., Zhang, X., Fischer, R.L., Huh, J., and Hsieh, T.F. (2019) The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis.Proceedings of the National Academy of Sciences USA, 116(35):17563-17571 (*: equal contribution).

5.Kirkbride, R.C.*, Lu, J.*,Zhang, C.*, Mosher, R.A., Baulcombe, D.C., and Chen, Z.J. (2019) Maternal small RNAs mediate spatial-temporal regulation of gene expression, imprinting, and seed development in Arabidopsis.Proceedings of the National Academy of Sciences USA, 116 (7): 2761-2766 (*: equal contribution).

6.Shi, X.,Zhang, C., Ko, D.K., Chen, Z.J. (2015) Genome-wide dosage-dependent and -independent regulation contributes to gene expression and evolutionary novelty in plant polyploids.Molecular Biology and Evolution, 32(9):2351-2366.

7.Kirkbride, R.C., Yu, H.H., Nah, G.,Zhang, C., Shi, X., Chen, Z.J. (2015) An epigenetic role for disrupted paternal gene expression in postzygotic seed abortion in Arabidopsis interspecific hybrids.Molecular Plant, 8 1766-1775.

8.Tian, L., Li, X., Ha, M.,Zhang, C., Chen, Z.J. (2014) Genetic and epigenetic changes in a genomic region containing MIR172 in Arabidopsis allopolyploids and their progenitors.Heredity(Edinb), 112 207-214.

9.Zhang C.and Hsieh T.F. (2013) Heritable Epigenetic Variation and its Potential Applications for Crop Improvement.Plant Breeding & Biotechnology, 1: 307-319.

10.Shi, X.*, Ng, D.*,Zhang, C.*, Comai, L., Ye, W. and Chen, Z.J. (2012) Cis- and trans -regulatory divergence between progenitor species determines gene-expression novelty in Arabidopsis allopolyploids.Nature Communications, 3:950. doi: 10.1038/ncomms1954 (*: equal contribution).

11.Zhang, C.^#& Galbraith, D.W. (2012) RNA interference-mediated gene knockdown within specific cell types.Plant Molecular Biology, 80(2):169-76.

12.Lu, J.,Zhang, C., Baulcombe, D.C. and Chen, Z.J. (2012) Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds.Proceedings of the National Academy of Sciences USA, 109, 5529-5534.

13.Miller, M.,Zhang, C.and Chen, Z.J. (2012) Ploidy and Hybridity Effects on Growth Vigor and Gene Expression inArabidopsis thalianaHybrids and Their Parents.G3: Genes| Genomes| Genetics, 2, 505-513.

14.Ng, D.,Zhang, C., Miller, M., Shen, Z., Briggs, S.P. and Chen, Z.J. (2012) Proteomic divergence in Arabidopsis autopolyploids and allopolyploids and their progenitors.Heredity, 108, 419-430.

15.Zhang, C., Ng, D., Lu, J. and Chen, Z.J. (2012) Roles of target site location and sequence complementarity in trans-acting siRNA formation in Arabidopsis.Plant Journal, 69, 217-226.

16.Ng, D.,Zhang, C., Miller, M., Palmer, G., Whiteley, M., Tholl, D. and Chen, Z.J. (2011) cis- and trans-Regulation of miR163 and Target Genes Confers Natural Variation of Secondary Metabolites in Two Arabidopsis Species and Their Allopolyploids.Plant Cell, 23, 1729-1740.

17.Zhu, J., Lee, B.-H., Dellinger, M., Cui, X.,Zhang, C., Wu, S., Nothnagel, E.A. and Zhu, J.-K. (2010) A cellulose synthase-like protein is required for osmotic stress tolerance in Arabidopsis.Plant Journal, 63, 128-140.

18.Wang, D.,Zhang, C., Hearn, D.J., Kang, I.H., Punwani, J.A., Skaggs, M.I., Drews, G.N., Schumaker, K.S. and Yadegari, R. (2010) Identification of transcription-factor genes expressed in the Arabidopsis female gametophyte.BMC Plant Biology, 10:110. doi: 10.1186/1471-2229-10-110.

19.Zhang, C., Barthelson, R.A., Lambert, G.M. and Galbraith, D.W. (2008) Global characterization of cell-specific gene expression through fluorescence-activated sorting of nuclei.Plant Physiology, 147, 30-40.

20.Coury, D.A.,Zhang, C., Ko, A., Skaggs, M.I., Christensen, C.A., Drews, G.N., Feldmann, K.A. and Yadegari, R. (2007) Segregation distortion in Arabidopsis gametophytic factor 1 (gfa1) mutants is caused by a deficiency of an essential RNA splicing factor.Sexual Plant Reproduction, 20, 87-97.

21.Zhang, C., Gong, F., Lambert, G.M. and Galbraith, D.W. (2005) Cell type-specific characterization of nuclear DNA contents within complex tissues and organs.Plant Methods, 1, 7.

22.Wang, Z., Li, P., Fredricksen, M., Gong, Z., Kim, C.S.,Zhang, C., Bohnert, H.J., Zhu, J.K., Bressan, R.A., Hasegawa, P.M., Zhao, Y. and Zhang, H. (2004) Expressed sequence tags from Thellungiella halophila, a new model to study plant salt-tolerance.Plant Science, 166, 609-616.

23.Inan, G., Zhang, Q., Li, P., Wang, Z., Cao, Z., Zhang, H.,Zhang, C., Quist, T.M., Goodwin, S.M., Zhu, J., Shi, H., Damsz, B., Charbaji, T., Gong, Q., Ma, S., Fredricksen, M., Galbraith, D.W., Jenks, M.A., Rhodes, D., Hasegawa, P.M., Bohnert, H.J., Joly, R.J., Bressan, R.A. and Zhu, J.K. (2004) Salt cress. A halophyte and cryophyte Arabidopsis relative model system and its applicability to molecular genetic analyses of growth and development of extremophiles.Plant Physiology, 135, 1718-1737.

24.Guo, Y., Qiu, Q., Quintero, F.J., Pardo, J.M., Ohta, M.,Zhang, C., Schumaker, K.S. and Zhu, J.K. (2004) Transgenic evaluation of activated mutant alleles of SOS2 reveals a critical requirement for its kinase activity and C-terminal regulatory domain for salt tolerance inArabidopsis thaliana.Plant Cell, 16, 435-449.

25.Gong, D.,Zhang, C., Chen, X., Gong, Z. and Zhu, J.K. (2002) Constitutive activation and transgenic evaluation of the function of an Arabidopsis PKS protein kinase.Journal of Biological Chemistry, 277, 42088-42096.

26.Zhu, J., Gong, Z.,Zhang, C., Song, C., Damsz, B., Inan, G., Koiwa, H., Zhu, J.K., Hasegawa, P.M. and Bressan, R.A. (2002) OSM1/SYP61: A syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid-mediated responses to abiotic stress.Plant Cell, 14, 3009-3028.

27.Xiong, L., Lee, B.-H., Ishitani, M., Lee, H.,Zhang, C.and Zhu, J.K. (2001) FIERY1 encoding an inositol polyphosphate 1-phosphatase is a negative regulator of abscisic acid and stress signaling in Arabidopsis.Gene & Development, 15, 1971-1984.

28.Bressan, R.A.,Zhang, C., Zhang, H., Hasegawa, P.M., Bohnert, H.J. and Zhu, J.K. (2001) Learning from the Arabidopsis experience. The next gene search paradigm.Plant Physiology, 127, 1354-1360.

29.Jia, S.R., Lu, Q.,Zhang, C.(1999)Safety evaluation of transgenic plants. In: (Zhu. S., edited) Safety Evaluation of Bioengineering. Chemistry Press.

30.Zhang, C., Lu, Q., Wang, Z., Jia, S.R. (1997)Frequency of 2, 4-D resistant gene flow from transgenic cotton.Scientia Agricultura Sinica30: 92-93.