卢福浩

Email：LUFUHAO@henu.edu.cn

研究方向：生物信息学/信息挖掘/基因组学/表观基因组学

卢福浩，男，博士

河南大学杰出人才特区特聘教授，河南大学作物逆境适应与改良国家重点实验室课题组PI，英国皇家生物学会会士。2012年毕业于韩国公州国立大学（Kongju National University），获理学博士学位。2012-2019年，在英国约翰英纳斯中心（John Innes Centre）长期致力于小麦/节节麦/拟南芥/油菜等植物的基因组学/转录组学/表观基因组学等相关研究，参与组装并分析了多个作物的基因组，如小麦TGACv1，小麦IWGSC v0.4，节节麦Aet_MR1.0，小麦chr3DL等；同时，致力于生物学与计算科学交叉领域的定向信息挖掘，生物信息学技术平台的搭建/编程/应用，利用自定义编程开发生物信息学新流程/新工具（https://github.com/lufuhao）。2019年，入职河南大学特聘教授，独立PI，组建生物信息学课题组。近5年来在TOP期刊发表文章6篇，总引用794次。

主要研究方向：

多倍体化通过杂种优势给植物带来丰富的抗逆资源。通过研究小麦/棉花/油菜/玉米等植物的基因组/转录组/表观基因组，深入了解并挖掘影响植物多倍体化以及形成杂种优势的关键基因，为现有作物引入更丰富的抗逆基因资源。目前，主要集中于以下几个方向：1）作物基因组学；2）多倍体化进程中基因的表达与适应；3）表观基因组学对多倍体化的贡献与影响。

讲授课程：

1.主讲研究生课程：《生物信息学》

2.主讲本科生课程：《生物信息学》

代表性研究论文（#第一作者; *通讯作者）

6. Charlotte N. Miller#, Jack Dumenil,Fu Hao Lu, Caroline Smith, Neil McKenzie, Volodymyr Chapman, Joshua Ball, Mathew Box, Michael Bevan *. Variation in the expression of a transmembrane protein influences cell growth in Arabidopsis thaliana petals by altering auxin responses. BMC Plant Biology 2020,20(1):482. doi: 10.1186/s12870-020-02698-5

5.Fu-Hao Lu#, Neil McKenzie, Laura-Jayne Gardiner, Ming-Cheng Luo, Anthony Hall, Michael W. Bevan *. Reduced chromatin accessibility underlies gene expression differences in homologous chromosome arms of diploidAegilops tauschiiand hexaploid wheat.GigaScience, 2020, 9(6):giaa070. doi: 10.1093/gigascience/giaa070

4.Fu-Hao Lu#, Neil McKenzie#, George Kettleborough, Darren Heavens, Matthew D. Clark, Michael W. Bevan*. Independent assessment and improvement of wheat genome sequence assemblies using Fosill jumping libraries.GigaScience,2018, 7(5): giy053. doi: 10.1093/gigascience/giy053

3. Ming-Cheng Luo#, Yong Q Gu#, Daniela Puiu#, Hao Wang#, Sven O Twardziok#, Karin R Deal, Naxin Huo, Tingting Zhu, Le Wang, Yi Wang, Patrick E McGuire, Shuyang Liu, Hai Long, Ramesh K Ramasamy, Juan C Rodriguez, Sonny L Van, Luxia Yuan, Zhenzhong Wang, Zhiqiang Xia, Lichan Xiao, Olin D Anderson, Shuhong Ouyang, Yong Liang, Aleksey V Zimin, Geo Pertea, Peng Qi, Jeffrey L Bennetzen, Xiongtao Dai, Matthew W Dawson, Hans-Georg Muller, Karl Kugler, Lorena Rivarola-Duarte, Manuel Spannagl, Klaus F X Mayer,Fu-Hao Lu, Michael W Bevan, Philippe Leroy, Pingchuan Li, Frank M You, Qixin Sun, Zhiyong Liu, Eric Lyons, Thomas Wicker, Steven L Salzberg*, Katrien M Devos*, Jan Dvorak*. Genome sequence of the progenitor of the wheat D genomeAegilops tauschii.Nature,2017, 551(7681):498-502. doi: 10.1038/nature24486

2. Bernardo J. Clavijo#, Luca Venturini#, Christian Schudoma, Gonzalo Garcia Accinelli, Gemy Kaithakottil, Jonathan Wright, Philippa Borrill, George Kettleborough, Darren Heavens, Helen Chapman, James Lipscombe, Tom Barker,Fu-Hao Lu, Neil McKenzie, Dina Raats, Ricardo H. Ramirez-Gonzalez, Aurore Coince, Ned Peel, Lawrence Percival-Alwyn, Owen Duncan, Josua Trösch, Guotai Yu, Dan M. Bolser, Guy Namaati, Arnaud Kerhornou, Manuel Spannagl, Heidrun Gundlach, Georg Haberer, Robert P. Davey, Christine Fosker, Federica Di Palma, Andrew L. Phillips, A. Harvey Millar, Paul J. Kersey, Cristobal Uauy, Ksenia V. Krasileva, David Swarbreck*, Michael W. Bevan*, Matthew D. Clark*. An improved assembly and annotation of the allohexaploid wheat genome identifies complete families of agronomic genes and provides genomic evidence for chromosomal translocations.Genome Research, 2017, 27(5):885-896. doi: 10.1101/gr.217117.116

1. Hui Dong#, Jack Dumenil#,Fu-Hao Lu#, Li Na#, Hannes Vanhaeren, Christin Naumann, Maria Klecker, Rachel Prior, Caroline Smith, Neil McKenzie, Gerhard Saalbach, Liangliang Chen, Tian Xia, Nathalie Gonzalez, Mathilde Seguela, Dirk Inzé, Nico Dissmeyer, Yunhai Li*, Michael W. Bevan*. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis.Genes & Development, 2017, 31(2):197-208. doi:10.1101/gad.292235.116.

学会会员：

1.英国皇家生物学会会士

2.中国植物学会会员

3.河南省肿瘤精准诊疗联盟创始会员